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Wine Rx

CBSNewsOnline :

Scientists have found a substance in red wine that is slowing down the aging process in mice. Will it someday lengthen the lives of humans, too? Morley Safer reports.







Resveratrol Grape Juice – Benefits and Side Effects

Resveratrol, an ingredient found in grapes and red wine, has often been linked to the explanation regarding the term ‘French paradox’, the puzzling fact that the French suffer less from heart related diseases, even though they enjoy a higher-fat diet than most Americans do.

This has led to research by scientists, who have now taken an interest in exploring how resveratrol might help in extending lifespan of a human.

They hope to use resveratrol grape juice or resveratrol based compound to provide the same effects as that of a severely restricted diet, which is supposed to extend lifespan of humans.  This is a low level caloric intake diet which activates a class of proteins, called sirtuin which in turn control metabolism; there are few other natural substances that can activate sirtuin, but resveratrol grape juice is particularly potent at triggering sirtuins.

This new interest that researchers have found in resveratrol grape juice, has led to several breakthroughs.


The scientists at Harvard University have proven that resveratrol grape juice helps in extending lifespan by controlling the activity of a gene associated with aging generally present in all life forms.

It has been practically demonstrated that while middle-aged mice which fed on a high-calorie diet suffered the deadly effects of obesity such as metabolic changes resembling diabetes, liver and cardiac damage, and premature death.

Mice which were fed with resveratrol along with the same high-calorie diet demonstrated healthy changes in their physiology, which were found in mice fed with standard diet.

The reason behind all age-related illness is oxidative stress.  It is responsible for numerous disease processes and for aging itself.

Resveratrol grape juice shows powerful antioxidant abilities capable of providing benefits for human health beyond imagination.

Scientists reports suggest that resveratrol grape juice improves the oxidation rate of dangerous low-density lipoprotein (LDL) and and helps in filtering out harmful hydroxyl radicals. Resveratrol grape juice also facilitates in maintenance of glutathione levels, our body’s major antioxidants.

According to one of the prominent resveratrol investigators, resveratrol grape juice is a very effective free-radical filters with many effects capable of affecting not only longevity but general health in common.

Resveratrol grape juice is capable of improving health and reduce the rate of aging process affecting many mechanisms such as potent antioxidant effects, capability to improve energy production at cellular level, and the ability to improve patterns of gene expression in the same manner as that of a low calorie-diet restriction would provide.

A word of caution though, few side effects such as increased sensitivity to temperature variations, increased adult acne have been noticed. So it is advisable to visit a doctor under such situations.







Resveratrol, The Fountain of Youth? Quite Possibly!

It has long been somewhat of a mystery as to why the French could eat a high fat, high calorie diet and have a lower incidence of heart disease and live long healthy lives.
It was known that wine had something to do with it but over the last couple of years, compliments of Dr Sinclair of the Harvard Medical Center and Rafael De Cabo Phd., they may have isolated the properties that answer the mystery.


The key is resveratrol in the fermented skins of the red wine grape, especially grapes that come from cooler climates.

There have been published papers on the fact that people (or animals for that matter) who have calorie restricted diets live longer.



Resveratrol does many things for the body including fooling the body into thinking it is calorie restricted. Hence, the French eating high calorie, high fat diets (with wine) may live longer with less incidence of heart disease.

Here is some interesting information on various studies on resveratrol and the promising results.

– According to a study done by the Dept. of Science and Technology at the Ohio State University in 1997, resveratrol was able at a cellular level to inhibit cancer cells from dividing. It also demonstrated that the estrogenic activity was able to prevent post-menopausal bone loss.

– The Dept of Microbiology-Immunology NE Ohio University, College of Medicine, successfully treated hairless mice that had herpes lesions. Repeated tests with topical resveratrol had the same results. In the same year it was also discovered that topical reseveratrol reduced skin cancer by as much as 98%.

– In Nov. of 2006, Dr Sinclair and Rafael De Cabo, did a study on middle aged mice and the findings were extremely encouraging.  The mice were divided into 3 groups; the 1st group was given a standard diet., the 2nd group a high fat, high calorie diet, and the 3rd group a high fat, high calorie diet with resveratrol.

The 2nd group of high fat, high calories soon developed symptoms of heart disease and diabetes and shortened lifespan.

The 3rd group with high fat, high calories and resveratrol had no symptoms of heart disease or diabetes and they were much more active than the second group even later in life.

The third group of mice also lived up to 30% longer. (The standard diet mice faired as well as the 3rd group)





– In another study in April of 2008, patients who were treated with resveratrol before receiving radiation treatments, found that pancreatic cancer cells would die off during radiation sessions. This is very encouraging because pancreatic cancer can be very difficult to treat.

– Now, very interesting, what does resveratrol have in common with Viagra? They both open restricted blood flow. Viagra is limited to small blood vessels but reseveratrol opens both small blood vessels and main arteries. The circulation benefits of resveratrol may outperform Viagra.

– The reasoning behind resevratrol being hailed as the potential fountain of youth is because taking resveratrol regularly has been demonstrated to reduce and or reverse DNA mishaps. Aging comes about when cells can no longer replicate cell DNA and thus begins the gradual decline of the body. Resveratrol stimulates what is called the longevity gene (caloric restricted diets) and it has been demonstrated that resveratrol reduces DNA mishaps by as much as a whopping 60%! Even if it was 30% that would be impressive!

There is still much studying to be done on resveratrol, especially on humans but the research so far has been more than promising. A glass of wine a day can be beneficial but good quality, pure resveratrol supplements have the potential for great health benefits.













Dr Oz Resveratrol Supplement Recommendation

There were plenty of things being announced about Resveratrol recently, almost all of which are the benefits that the same plant chemical can offer the body. But how about resveratrol supplements? Do they have similarly beneficial to someone’s health? Dr. Oz, whom had been featured numerous times on the Oprah Winfrey Show, recommends using the supplement. Let us see the reason why this plant chemical is making its way to the media’s attention nowadays.

What’s Resveratrol?

It’s a plant enzyme that’s ordinarily occuring in grape seeds, grape juice, red wine, and peanuts as well . Examining products made of this certain compound, the roots of the medicinal Japanese knotweed herb is the commonest source. Derivatives similar to red wine extracts, red grape and grape seed extracts, and alternative plant sources alternate in the amounts of resveratrol.



What are its benefits?

Experimentation shows that the compound can assist as an anti-inflammatory, anticancer, tempered estrogenic, antioxidant, antiplatelet, cholesterol reducing agent, and anti-aging agent. Promotion of the product , however , surpasses the base of clinical research. Studies about the claims on the results of using the product has not yet been approved by the FDA. However , the number of testimonials from folk who are using the product is increasing, and people are very enthusiastic plus are saying good things about it.

Howis it sold?

The FDA has actually refused the requests of many manufacturers to sell the product as a dietary supplement. The FDA claims these products do not have satisfactory evidence that will finally make it evident to be beneficial to humans. However, the product is still sold readily in the market in numerous forms, complexes and formulas offering 1mg to 100mg of resveratrol.

If you want to reap the benefits of this plant chemical, it’s still beneficial to consume fresh fruits and herbs that are loaded in the same compound. Buy yourself fresh grapefruits, peanuts, and other healthy foods instead.

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